The present research investigation carried out was aimed to develop a colon targeted tablet of mesalamine which can provide targeted release of drug into the colon. Gum dammar and neem gum was selected as a degradable polysaccharide to prepare core tablet using different concentration. Physicochemical properties of gum dammar and neem gum like color, acid value, softening point molecular weight were studied. The core tablets were coated with acid soluble polymer shellac and enteric polymer Inulin. Coated tablet were studied for post compression parameters. All the observations are within the prescribed limits. The in-vitro release results indicate that as an increase in the polymer concentration the release of drug extended and gum dammar based formulation shows more extends drug release compare to neem gum based formulation. FTIR Studies shows there was no interaction found between any excipient and drug.
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